Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans
J Immunol. 2009 Apr 15;182(8):4891-8. doi: 10.4049/jimmunol.0803776. ABSTRACT Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position of cell membrane phospholipids to release fatty acids and lysophospholipids.
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation
J Immunol. 2013 Jun 15;190(12):5927-38. doi: 10.4049/jimmunol.1203202. Epub 2013 May 6. ABSTRACT We reported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Efficacy and safety of drug-coated balloon in the treatment of acute myocardial infarction: a meta-analysis of randomized controlled trials
Sci Rep. 2022 Apr 21;12(1):6552. doi: 10.1038/s41598-022-10124-z. ABSTRACT Acute myocardial infarction (AMI) is one of the main causes of death in the world, and the
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Cell. 2022 Feb 2:S0092-8674(22)00067-8. doi: 10.1016/j.cell.2022.01.009. Online ahead of print. ABSTRACT Activation of the innate immune system via pattern recognition receptors (PRRs) is key to
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome