Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice
Sci Rep. 2020 Oct 28;10(1):18443. doi: 10.1038/s41598-020-75601-9. ABSTRACT Riboflavin transporter 3 (RFVT3), encoded by the SLC52A3 gene, is important for riboflavin homeostasis in the small
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. ABSTRACT Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation
J Immunol. 2013 Jun 15;190(12):5927-38. doi: 10.4049/jimmunol.1203202. Epub 2013 May 6. ABSTRACT We reported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
J Immunol. 2014 Mar 15;192(6):2812-20. doi: 10.4049/jimmunol.1301794. Epub 2014 Feb 12. ABSTRACT We previously established a mast cell (MC)-dependent thermal injury model in mice with
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022087118. doi: 10.1073/pnas.2022087118. ABSTRACT Acute and chronic itch are burdensome manifestations of skin pathologies including allergic