Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6
J Immunol. 2013 Feb 15;190(4):1758-66. doi: 10.4049/jimmunol.1202567. Epub 2013 Jan 14. ABSTRACT Mast cells (MC) and basophils share expression of the high-affinity receptor for IgE
Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial
Am J Respir Crit Care Med. 2019 Sep 15;200(6):704-711. doi: 10.1164/rccm.201809-1755OC. ABSTRACT Rationale: Daily high-dose aspirin therapy benefits many patients with aspirin-exacerbated respiratory disease but
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Cell Stem Cell. 2021 Dec 25:S1934-5909(21)00520-8. doi: 10.1016/j.stem.2021.12.010. Online ahead of print. ABSTRACT Kidney failure is frequently observed during and after COVID-19, but it remains
Efficacy and safety of dupilumab in patients with uncontrolled severe CRSwNP and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials
Allergy. 2021 Aug 30. doi: 10.1111/all.15067. Online ahead of print. ABSTRACT BACKGROUND: About one-tenth of patients with difficult-to-treat chronic rhinosinusitis with nasal polyps (CRSwNP) have
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial
JAMA. 2021 Sep 21;326(11):1013-1023. doi: 10.1001/jama.2021.13374. ABSTRACT IMPORTANCE: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared
Allergic inflammatory memory in human respiratory epithelial progenitor cells
Nature. 2018 Aug;560(7720):649-654. doi: 10.1038/s41586-018-0449-8. Epub 2018 Aug 22. ABSTRACT Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases1. Specialized subsets of