Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation
Sci Immunol. 2021 Dec 24;6(66):eabj0474. doi: 10.1126/sciimmunol.abj0474. Epub 2021 Dec 24. ABSTRACT [Figure: see text]. PMID:34932383 | DOI:10.1126/sciimmunol.abj0474
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. ABSTRACT Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis
GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11685-90. doi: 10.1073/pnas.0905364106. Epub 2009 Jun 26. ABSTRACT The cysteinyl leukotrienes (cys-LTs) are proinflammatory lipid mediators
Efficacy and safety of dupilumab in patients with uncontrolled severe CRSwNP and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials
Allergy. 2021 Aug 30. doi: 10.1111/all.15067. Online ahead of print. ABSTRACT BACKGROUND: About one-tenth of patients with difficult-to-treat chronic rhinosinusitis with nasal polyps (CRSwNP) have
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Cell. 2022 Feb 2:S0092-8674(22)00067-8. doi: 10.1016/j.cell.2022.01.009. Online ahead of print. ABSTRACT Activation of the innate immune system via pattern recognition receptors (PRRs) is key to
Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6
J Immunol. 2013 Feb 15;190(4):1758-66. doi: 10.4049/jimmunol.1202567. Epub 2013 Jan 14. ABSTRACT Mast cells (MC) and basophils share expression of the high-affinity receptor for IgE