The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation
Sci Immunol. 2018 Oct 5;3(28):eaat9453. doi: 10.1126/sciimmunol.aat9453. ABSTRACT Respiratory epithelial cells (EpCs) orchestrate airway mucosal inflammation in response to diverse environmental stimuli, but how distinct
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
J Immunol. 2014 Mar 15;192(6):2812-20. doi: 10.4049/jimmunol.1301794. Epub 2014 Feb 12. ABSTRACT We previously established a mast cell (MC)-dependent thermal injury model in mice with
Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units
Genome Med. 2021 Nov 17;13(1):182. doi: 10.1186/s13073-021-00991-y. ABSTRACT BACKGROUND: Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service
Normal IgH Repertoire Diversity in an Infant with ADA Deficiency After Gene Therapy
J Clin Immunol. 2021 Oct;41(7):1597-1606. doi: 10.1007/s10875-021-01034-2. Epub 2021 Jun 28. ABSTRACT PURPOSE: Adenosine deaminase (ADA) deficiency causes severe combined immunodeficiency (SCID) through an accumulation
Asthma Exacerbations in Patients with Type 2 Diabetes and Asthma on Glucagon-like Peptide-1 Receptor Agonists
Am J Respir Crit Care Med. 2021 Apr 1;203(7):831-840. doi: 10.1164/rccm.202004-0993OC. ABSTRACT Rationale: GLP-1R (glucagon-like peptide-1 receptor) agonists are approved to treat type 2 diabetes