SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome
Pharmacokinetic-pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats
Sci Rep. 2020 Nov 2;10(1):18876. doi: 10.1038/s41598-020-76007-3. ABSTRACT The relationship between the plasma insulin (INS) concentration-time course and plasma glucose concentration-time course during and after
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation
Sci Immunol. 2018 Oct 5;3(28):eaat9453. doi: 10.1126/sciimmunol.aat9453. ABSTRACT Respiratory epithelial cells (EpCs) orchestrate airway mucosal inflammation in response to diverse environmental stimuli, but how distinct
KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
N Engl J Med. 2017 May 18;376(20):1911-1920. doi: 10.1056/NEJMoa1613125. ABSTRACT BACKGROUND: Mast cells are present in the airways of patients who have severe asthma despite
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
J Immunol. 2014 Mar 15;192(6):2812-20. doi: 10.4049/jimmunol.1301794. Epub 2014 Feb 12. ABSTRACT We previously established a mast cell (MC)-dependent thermal injury model in mice with
Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1174-9. doi: 10.1073/pnas.0337567100. Epub 2003 Jan 14. ABSTRACT Eosinophils are implicated prominently in allergic diseases and