Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation
Sci Immunol. 2021 Dec 24;6(66):eabj0474. doi: 10.1126/sciimmunol.abj0474. Epub 2021 Dec 24. ABSTRACT [Figure: see text]. PMID:34932383 | DOI:10.1126/sciimmunol.abj0474
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
J Immunol. 2014 Mar 15;192(6):2812-20. doi: 10.4049/jimmunol.1301794. Epub 2014 Feb 12. ABSTRACT We previously established a mast cell (MC)-dependent thermal injury model in mice with
Machine learning approaches reveal genomic regions associated with sugarcane brown rust resistance
Sci Rep. 2020 Nov 18;10(1):20057. doi: 10.1038/s41598-020-77063-5. ABSTRACT Sugarcane is an economically important crop, but its genomic complexity has hindered advances in molecular approaches for
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Asthma Exacerbations in Patients with Type 2 Diabetes and Asthma on Glucagon-like Peptide-1 Receptor Agonists
Am J Respir Crit Care Med. 2021 Apr 1;203(7):831-840. doi: 10.1164/rccm.202004-0993OC. ABSTRACT Rationale: GLP-1R (glucagon-like peptide-1 receptor) agonists are approved to treat type 2 diabetes