Novel Treatments for Airway Disease
N Engl J Med. 2017 Aug 10;377(6):597. doi: 10.1056/NEJMc1708004. NO ABSTRACT PMID:28813135 | DOI:10.1056/NEJMc1708004
Expression profiling of constitutive mast cells reveals a unique identity within the immune system
Nat Immunol. 2016 Jul;17(7):878-87. doi: 10.1038/ni.3445. Epub 2016 May 2. ABSTRACT Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma
J Immunol. 2014 Nov 15;193(10):4783-4789. doi: 10.4049/jimmunol.1302947. Epub 2014 Oct 15. ABSTRACT Allergic asthma is a complex disease with a strong genetic component where mast
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation
Sci Immunol. 2018 Oct 5;3(28):eaat9453. doi: 10.1126/sciimmunol.aat9453. ABSTRACT Respiratory epithelial cells (EpCs) orchestrate airway mucosal inflammation in response to diverse environmental stimuli, but how distinct
Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans
PLoS One. 2016 Jul 8;11(7):e0158893. doi: 10.1371/journal.pone.0158893. eCollection 2016. ABSTRACT Anion exchanger 2 (Ae2; gene symbol, Slc4a2) is a plasma membrane Cl-/HCO3- exchanger expressed in